18-METHOXYCORONARIDINE AND THE HABENULO-INTERPEDUNCULAR PATHWAY

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Auf Lager.
Artikelnummer:
1002097
  • Produktbeschreibung

    18-METHOXYCORONARIDINE AND THE HABENULO-INTERPEDUNCULAR PATHWAY

    Opioid addiction is a major public health §problem and the need for new efficient therapies is §immense.18-Methoxycoronaridine (18-MC), an iboga §alkaloid congener, has been previously shown to §reduce the self-administration of several drugs of §abuse, including opioids.18-MC is a potent §antagonist of alpha3beta4 nicotinic receptors and §this now appears to be the primary mechanism of 18-§MC s action in the brain. These nicotinic receptors §are present in high densities in the nuclei of the §habenulo-interpeduncular pathway but §not in the mesolimbic pathway, known to be involved §in drug addiction.This book describes the modulation §of the mesolimbic pathway by the habenulo-§interpeduncular pathway during chronic exposure to §opioids and examines the role of 18-MC, nicotinic §receptors and acetylcholine in such modulation.This §book also illustrates the contribution of the latter §pathway in 18-MC s ability to attenuate opioid §withdrawal.The findings described in the book §provide evidence that alpha3beta4 nicotinic §receptors could be a novel target for anti-addictive §therapies.The monograph should be useful to §pharmacologists and behavioral neuroscientists.
  • Zusatzinformation

    Autor
    Bindung
    Taschenbuch
    Verlag
    VDM Verlag Dr. Müller
    ISBN / EAN
    9783639137743
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