Studies Toward the Synthesis of Lomaiviticins and Englerins

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Auf Lager.
Artikelnummer:
1090194
  • Produktbeschreibung

    Studies Toward the Synthesis of Lomaiviticins and Englerins

    Part I: Lomaiviticins A and B are novel C2-symmetric dimeric molecules with profound cytotoxic activity. The most challenging feature of these molecules is the densely functionalized central core. We envisioned the synthesis of the lomaiviticin core by an unprecedented Diels-Alder dimerization of ortho- quinols and masked ortho-benzoquinones, followed by the fragmentation of the extra carbon-carbon bond. This chapter describes the stereoselective elaboration of the ortho-quinol and masked ortho- benzoquinone dimers to the fragmentation precursors and the unsuccessful attempts to effect the scission of the extra bond. Part II: Englerin A is a new guaiane sesquiterpene and has been shown to be a selective renal cancer inhibitor. We envisioned the synthesis of englerin A via a novel strategy featuring Wagner-Meerwein rearrangement followed by intramolecular cation trapping. This chapter describes the stereoselective synthesis of the key cis-decalin intermediate from (-)-carvone and the unsuccessful attempts to realize the skeletal rearrangement.
  • Zusatzinformation

    Autor
    Bindung
    Taschenbuch
    Verlag
    VDM Verlag Dr. Müller
    ISBN / EAN
    9783639369885
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