Formualtion of Sublingual Films

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Artikelnummer:
1145036
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    Formualtion of Sublingual Films

    Sublingual drug delivery has now been recognized as a very promising route for delivery of therapeutic compounds including biopharmaceuticals. The sublingual mucosa offers a large, very thin, highly vascularised layer for efficient absorption of drug. Buspirone hydrochloride gets completely absorbed from the gastrointestinal tract after oral doses but undergoes extensive firstpass metabolism with a bioavailability of about 5%. Oral solid dosage form i.e. tablet is most commonly used formulation in the market. However, its high first pass metabolism leads to low bioavailability demands exploring other drug delivery routes to improve bioavailability. Sublingual route may serve as better route for delivery of such kind of drugs which are having high first pass metabolism by oral route.
  • Zusatzinformation

    Autor
    Bindung
    Taschenbuch
    Verlag
    LAP Lambert Academic Publishing
    ISBN / EAN
    9783659474170
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