The digital transformation is accompanied by two simultaneous processes: digital humanities challenging the humanities, their theories, methodologies and disciplinary identities and pushing computer science to get involved in new fields. But how can qualitative and quantitative methods be usefully combined in one research project? What are the theoretical and methodological principles across all disciplinary digital approaches? This volume focusses on driving innovation and conceptualising the humanities in the 21st century. Building on the results of 10 research projects, it serves as a useful tool for designing cutting-edge research that goes beyond conventional strategies.