Seis Hermanos is a hamlet (caserío) in the Canelones Department of southern Uruguay. It is located on Route 6, about 0.6 kilometres (0.37 mi) southwest of its intersection with Route 7 and Route 74. It is 8 kilometres (5.0 mi) south of the city of Sauce and 4 kilometres (2.5 mi) northeast of the town of Toledo. The Canelones Department (Spanish: Departamento de Canelones), with an area of 4,536 km² (1,752 square miles) and 485,240 inhabitants, is located to the south of Uruguay. Its capital is Canelones.