Pyrazolopyrimidine derivatives as cyclin-dependant kinase inhibitors

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Artikelnummer:
998187
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    Pyrazolopyrimidine derivatives as cyclin-dependant kinase inhibitors

    This book contains both review and synthesis of new pyrazolo[3,4-d]pyrimidine derivatives as cycline dependent kinase inhibitors (CDKIs). Moreover, cytotoxic activity for the newly synthesized compounds were evaluated, specially on breast cancer cell line (MCF-7). The results obtained were compared with methotrexate as a reference drug. Docking study and molecular modeling were also done using MOE program. I hope this work to be helpful and a starting point for much more new compounds with better activity to help in treatment of such a big terrible disease like cancer. Author: Phoebe F. Lamie
  • Zusatzinformation

    Autor
    Bindung
    Taschenbuch
    Verlag
    LAP Lambert Academic Publishing
    ISBN / EAN
    9783659792991
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